Whether you know it as the fat loss job, Ozempic, Wagovee, or Monjaro, GLP-1 drugs are growing in popularity as people look for help losing weight.
But what are these drugs exactly?
How do they work?
And what are the pros and cons?
Here’s a quick summary from the personal trainers at The One Percent Club Marylebone
What are GLP-1s?
GLP-1 stands for Glucagon-Like Peptide-1 — a hormone your body naturally produces in the gut after eating. GLP-1 receptor agonist medications such as Ozempic, Mounjaro and Wegovy mimic this hormone to regulate blood sugar, appetite and digestion. They were originally developed to treat Type 2 diabetes and are now widely prescribed for weight management.
How do they work?
Appetite Regulation - They send a signal to the brain that you are full and therefore reduce hunger and cravings.
Slow Gastric Emptying - Food moves through the stomach more slowly, prolonging the feeling of fullness.
Insulin Secretion - They stimulate the pancreas to release insulin in response to blood sugar rises.
Glucagon Suppression - Reduce the liver's release of stored glucose, helping stabilise blood sugar levels.
What are the pros?
Significant weight loss — clinical trials show average losses of 10–15% body weight
Improved blood sugar control in Type 2 diabetes
Reduced cardiovascular risk — evidence of lower rates of heart attack and stroke in high-risk individuals
Improved blood pressure and cholesterol markers
Reduced hunger and food noise
What are the cons?
Muscle loss- up to 50% with some drugs
Weight regain when stopping
Common side effects- Nausea, vomiting, diarrhoea and constipation are very common
Unknown long term safety data
Gallstone risk
Nutritional deficiencies
Thats the key facts you need to know and we ell explore the pros and cons in more detail in the next blog post.
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